Advanced Therapies in Ulcerative Colitis

PRE-TESTING AND VACCINATION

For more detailed information on vaccinations, please see the CANIBD Vaccination Guide

TB skin test
Blood work (baseline CBC, renal and liver function, HBV)

Ensure all immunizations are current.
Wait at least four weeks to start following administration of live vaccination.
Pneumococcal vaccination recommended for adult patients.
Recommend vaccinations HAV, HBV, HPV, and Tdap.
Refer to CANIBD Vaccination Guidelines for further information.16

Use with caution in patients with chronic or recurrent infection.

Liver tests as per routine patient management prior to initiating therapy.

METHOD OF ADMINISTRATION

IV infusion x 3
Then on-body (SC) injector (OBI) with pre-filled cartridge

LOCATION

Infusion centre
Home

DOSING

Induction:
1200mg IV at wk 0, wk 4 and wk 8

Then 180mg or 360 mg SC (OBI) at
wk 12 and every 8 wks thereafter

TIME REQUIRED

Minimum 1 hr infusion
OBI injection <15 min

ROUTINE MONITORING

Annual cervical cancer screening – pap test

Annual skin exam – skin malignancies

Influenza vaccine recommended

Screening for osteoporosis with bone mineral density testing periodically after diagnosis

Liver enzymes as part of your routine blood work.