Baseline ECG In patients with pre-existing conditions, advice from a cardiologist should be sought.
Blood work (baseline CBC, renal and liver function)
Opthalmic assessment in patients with a history of diabetes, uveitis or retinal disease.
Ensure all immunizations are current. Refer to CANIBD Vaccination Guidelines for further information14
Contraindications:
Last 6 months: myocardial infarction, unstable angina, pectoris, stroke, transient ischemic attack, decompensated heart failure, Mobitz type II second-degree or third-degree atrioventricular block, sick sinus syndrome, or sino-atrial block, unless the patient has a functioning pacemaker, immunocompromised, severe active infections, active malignancies
METHOD OF ADMINISTRATION
Oral
LOCATION
Home
DOSING
Induction/loading: 2 mg tablet once daily
Due to risk of transient decreases in heart rate, first dose cardiac monitoring recommended if there has been abnormality on baseline ECG.
Please refer to product monograph.
TIME REQUIRED
5 min
ROUTINE
MONITORING
Baseline bloodwork: Liver enzymes, ECG and ophthalmic evaluation. Follow up blood work as clinically indicated.
Blood pressure should be monitored during treatment and managed appropriately.
Patients with a history of diabetes mellitus, uveitis or retinal disease undergo follow up ophthalmologic evaluations while receiving therapy.