PRE-TESTING AND VACCINATION

For more detailed information on vaccinations, please see the CANIBD Vaccination Guide

Baseline ECG

Ensure all immunizations are up to date. Refer to CANIBD Vaccination Guidelines for further information.14

Blood work (baseline LFTs and CBC)

Contraindications:

MAO inhibitors
Last 6 months: myocardial infarction, unstable angina, stroke, TIA, decompensated heart failure, 2nd-degree AV block type II or 3rd-degree AV block, sick sinus syndrome or sinoatrial block unless patient has a pacemaker, pregnancy, severe infection, or active malignancies

METHOD OF ADMINISTRATION

Oral

LOCATION

Home

DOSING

Induction/loading:
Days 1–4: 0.23 mg
Day 5–7: 0.46 mg
Day 8 / Maintenance: 0.92 mg

TIME REQUIRED

5 mins

ROUTINE MONITORING

Before treatment initiation:  Baseline ECG, LFTs, CBC, VZV, negative pregnancy test

Only for patients at risk:  Ophthalmic evaluation, consult cardiologist, and 6-hr first dose observation

Patients should be monitored for any new onset of neurological or visual signs and symptoms and onset bradycardia.

LFTs and CBC