Chest X-ray TB skin test Blood work (baseline CBC, renal and liver function, HBV)
Ensure all immunizations are current. Wait at least four weeks to start following administration of live vaccination. Pneumococcal vaccination recommended for adult patients. Recommend vaccinations: HAV, HBV, HPV, and Tdap Refer to CANIBD Vaccination Guidelines for further information.14
Use with caution in patients with chronic or recurrent infection.
METHOD OF ADMINISTRATION
IV infusion x 1 then SC injection
LOCATION
Infusion centre Home
DOSING
Induction: weight based at 6mg/kg up to 55kg- 260mg >55kg-85kg- 390mg >85 kg- 520mg then maintenance 90 mg SC every 8 wks*
Following the first SC dose at 8 wks, those with low inflammatory burden may receive 90mg SC every 12 wks at the discretion of the HCP.
Patients who experience a disease flare or are non-responsive, a shorter infusion interval (q 4 wks) may be considered.
TIME REQUIRED
1–2 hrs for initial IV infusion SC injection <15 min
ROUTINE
MONITORING
Annual cervical cancer screening – pap test Annual skin exam – skin malignancies Influenza vaccine recommended May consider therapeutic drug monitoring (TDM) if available Screening for osteoporosis with bone mineral density testing periodically after diagnosis